Inclusion Criteria:

1. Subjects who aged 18 years or older

2. Subjects whose written informed consent was obtained complying with the local
regulatory requirements prior to their participation in the trial

3. Subjects who have histologically or cytologically confirmed unresectable or
metastatic epithelial cancer of the exocrine pancreas. High-quality contrast-enhanced
CT scanning is required to evaluate resectability. Measurable disease is not
required.

4. Subjects with no other malignancy diagnosed within past five years except for:

- Cured non-melanoma skin cancer

- Cured cervical intraepithelial neoplasia (CIN)

- Cured In-situ cervical cancer (CIS)

5. Subjects who are ECOG performance status of ≤ 1