Inclusion Criteria:

- Histologically confirmed advanced or inoperable HCC

- Child-Pugh A liver function score

- Measurable disease with at least one unidimensionally measurable lesion per RECIST
1.0 guidelines with modifications

- Adequate organ and hematological function

- Men or women greater than or equal to 18 years old

- Eastern Cooperative Oncology Group (ECOG) performance status of 2 or less

Exclusion Criteria:

- Subject is eligible for a liver transplant per investigators discretion

- Any previous systemic chemotherapy for HCC

- History of arterial or venous thromboembolism within 12 months prior to enrollment

- History of clinically significant bleeding within 6 months prior to enrollment

- History of central nervous system metastases

- Clinically significant cardiovascular disease within 12 months

- Uncontrolled hypertension

- Subjects with a history of prior malignancy