Inclusion Criteria:

- Histologically confirmed WHO grades 3 to 4 malignant glioma

- Diagnosed recurrence or progression by clinical or radiological evidence

- Fit for intraarterial infusion and intravenous chemotherapy

- Adequate hepatic, renal, and hematologic function.

- Legal age ≥18 years

- Life expectancy ≥12 weeks

- Eastern Cooperative Oncology Group performance (ECOG) ≥2

- Chemotherapy completion ≥4 weeks prior and recovery from drug induced toxicities.

Exclusion Criteria:

- Active pregnancy

- Prior gene therapy

- Second primary tumor

- Gravidity, lactation, hypersensitivity to antiviral drugs, immunologic deficit,
active uncontrolled infections

- Requiring treatment with warfarin or any other anticoagulants