Using Advanced MR Imaging to Determine High Risk Areas in Patients With Malignant High Grade Gliomas and to Design Potential Radiation Plans
18 Years
N/A
Both
Brain Cancer, Glioma
Trial Information
Using Advanced MR Imaging to Determine High Risk Areas in Patients With Malignant High Grade Gliomas and to Design Potential Radiation Plans
Inclusion Criteria:
- Histopathologically proven diagnosis of high grade or low glioma
- Will undergo radiation therapy
- Patient and/or guardian is able to provide written informed consent prior to study
registration
- Age > or = to 18 years old
Exclusion Criteria:
- Claustrophobia
- Known allergic reaction to Gd-DTPA
- Renal insufficiency with recent (<3 month old) creatinine >2.0
- Any contraindication to MRI (e.g., pacemaker, aneurysm clip, tissue expander).
- Pregnant or nursing female
- Unable to cooperate for MRI and/or radiation therapy planning
Type of Study:
Interventional
Study Design:
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Diagnostic
Outcome Measure:
To assess the utility of baseline advanced MRI & changes between baseline & follow up advanced MRI in predicting high risk areas that are likely to develop progressive glioma despite chemoradiotherapy.
Outcome Time Frame:
1 -7 weeks before radiation treatment, about two months after treatment, and about every two months thereafter for the duration of the study.
Safety Issue:
No
Principal Investigator
Robert Young, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Memorial Sloan-Kettering Cancer Center
Authority:
United States: Institutional Review Board
Study ID:
09-009
NCT ID:
NCT00870129
Start Date:
March 2009
Completion Date:
March 2014
Related Keywords:
- Brain Cancer
- Glioma
- brain tumor
- radiation
- MRI
- 09-009
- Brain Neoplasms
- Glioma
Name | Location |
|---|---|
| Memorial Sloan-Kettering Cancer Center | New York, New York 10021 |
