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Using Advanced MR Imaging to Determine High Risk Areas in Patients With Malignant High Grade Gliomas and to Design Potential Radiation Plans


N/A
18 Years
N/A
Open (Enrolling)
Both
Brain Cancer, Glioma

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Trial Information

Using Advanced MR Imaging to Determine High Risk Areas in Patients With Malignant High Grade Gliomas and to Design Potential Radiation Plans


Inclusion Criteria:



- Histopathologically proven diagnosis of high grade or low glioma

- Will undergo radiation therapy

- Patient and/or guardian is able to provide written informed consent prior to study
registration

- Age > or = to 18 years old

Exclusion Criteria:

- Claustrophobia

- Known allergic reaction to Gd-DTPA

- Renal insufficiency with recent (<3 month old) creatinine >2.0

- Any contraindication to MRI (e.g., pacemaker, aneurysm clip, tissue expander).

- Pregnant or nursing female

- Unable to cooperate for MRI and/or radiation therapy planning

Type of Study:

Interventional

Study Design:

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Investigator), Primary Purpose: Diagnostic

Outcome Measure:

To assess the utility of baseline advanced MRI & changes between baseline & follow up advanced MRI in predicting high risk areas that are likely to develop progressive glioma despite chemoradiotherapy.

Outcome Time Frame:

1 -7 weeks before radiation treatment, about two months after treatment, and about every two months thereafter for the duration of the study.

Safety Issue:

No

Principal Investigator

Robert Young, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center

Authority:

United States: Institutional Review Board

Study ID:

09-009

NCT ID:

NCT00870129

Start Date:

March 2009

Completion Date:

March 2014

Related Keywords:

  • Brain Cancer
  • Glioma
  • brain tumor
  • radiation
  • MRI
  • 09-009
  • Brain Neoplasms
  • Glioma

Name

Location

Memorial Sloan-Kettering Cancer CenterNew York, New York  10021