SBRT Radiotherapy for Non-operated Non-small-cell Lung Cancer (NSCLC), T1-T2, N0, M0
The main objective of this study is to do a health economic evaluation of innovating
techniques in radiotherapy.
SBRT is the very precise delivery of high-powered radiation to small target volumes, using
multiple low-intensity beams. Extremely precise patient positioning and target location is
essential for accurate treatment delivery.
Several studies have shown a benefit of SBRT in terms of local control and progression-free
survival, in particular for the treatment of cerebral metastases of limited number and size.
The development of this technique is recent. The number of treatment sessions is low: 1 to
But the patient is exposed to a major risk of toxicity in several organs: the bronchi, the
lungs, large vessels, the oesophagus and the spinal-cord.
Pulmonary SBRT imposes strict rules and the use of specific equipment.
Extra-cranial SBRT can be realized using either:
- Conventional linear-accelerator equipped SBRT,
- Cyberknife SBRT.
3 groups of treatment will be evaluated in this study:
- SBRT by cyberknife,
- SBRT by linear accelerator,
- Conformational radiotherapy (free breathing or breath holding).
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Evaluation of local control in patients with non-operated, non-metastatic non-small-cell lung cancer treated by radiotherapy
Line CLAUDE, MD
Centre Léon Bérard, LYON
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)