The Role Of Fructose and Uric Acid In the Development of Obesity and Metabolic Syndrome
Overweight and obesity are now considered a growing public health problem in Mexico and
worldwide. This epidemic has been attributed to dietary fructose consumption. Although
experimental models have demonstrated a role of fructose in the development of obesity,
metabolic syndrome and kidney disease, data in human models is lacking. The purpose of this
study is to determine if a low fructose intake could have an impact on the components of the
metabolic syndrome. The primary endpoint will be to determine the impact of low fructose on
weight loss. Secondary endpoints will evaluate the impact of low fructose diet on blood
pressure and cardiovascular biochemical profile.
If fructose is a causal pathway to obesity and metabolic syndrome, it may represent an
important target to mitigate this important health problem.
Interventional
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Screening
Somatometry: including weight, height, Body Mass Index (BMI), % Body fat levels, waist and hip index, and blood pressure levels measurements performed by a single evaluator and calibrated equipment
measurements will be performed by a trained evaluator
results obtained at the same day of evaluation (weekly monitoring during 6 weeks for each patient)
Yes
Magdalena Madero, MD
Principal Investigator
Instituto Nacional de CardiologĂa Ignacio Chávez
Mexico: National Institute of Public Health, Health Secretariat
FRUCTOSE 09-630
NCT00868673
March 2009
February 2010
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