Effects of a Western-type Diet on Colorectal Inflammation, Gut Permeability and Systemic Endotoxemia
Hypothesis: Compared to a prudent-style diet, does a western-style diet increase colorectal
inflammation thereby increasing gut permeability and causing increased endotoxins and
markers of systemic inflammation.
This is a single blind crossover study. Subjects will be randomized to begin on either a WD
or a PD for 30 + 3 days. Once that dietary intervention is complete, subjects will have a
four (4) week wash-out period and then will be placed on the other dietary intervention for
30 + 3 days. The following study measures are performed during both the dietary intervention
study periods. All the baseline tests will be repeated at the end of each dietary
intervention period.
Interventional
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Basic Science
Inflammation in the rectosigmoid epithelium
visit 1, 30 days after the first dietary intervention and 30 days after the second dietary intervention
No
Swaroop Pendyala, MD
Principal Investigator
Rockefeller University
United States: Institutional Review Board
SWP-0658
NCT00866450
February 2009
February 2010
Name | Location |
---|---|
Rockefeller University | New York, New York 10021 |