Inclusion Criteria:

- Histological diagnosis of non-small-cell lung cancer (NSCLC)

- Obtention of a biopsy of the tumour according to the procedure defined in the
protocol

- NSCLC of any stage to be treated by standard conventional first-line chemotherapy, as
defined in the ELCWP guidelines (www.elcwp.org)

- Presence of at least one assessable lesion

- Availability for participating in the detailed follow-up of the protocol

- Signed informed consent.

- Age above 18 years

Exclusion Criteria:

- Patient who was previously treated with chemotherapy for NSCLC or who has any
contra-indication precluding the administration of conventional chemotherapy for
NSCLC

- NSCLC treated by exclusive surgery or radiotherapy

- A history of prior malignant tumour, except non-melanoma skin cancer or in situ
carcinoma of the cervix or of the bladder or cured malignant tumour (more than 5-year
disease free interval)