Inclusion Criteria:

- Ability to understand and willingness to sign a written Informed Consent

- Advanced relapsed or refractory predominantly non squamous NSCLC. The diagnosis must
have been confirmed cyto-/ histologically

- Patients must have measurable or non-measurable disease

- At least two but not more than three prior standard treatment regimens for NSCLC

- ECOG Performance Status of 0 or 1

- Male or female subjects >/= 18 years of age (>/=20 for Japan) at the time of Informed
Consent

- Life expectancy of at least 12 weeks

- Ability to swallow oral medication

- Both men and women using adequate barrier birth control measures during the course of
the trial and 4 weeks after the completion of trial

- Adequate bone marrow, liver and renal function as assessed by the following
laboratory requirements to be conducted within 7 days prior to start of the study
drug:

- Haemoglobin > 9.0 g/dl

- Absolute neutrophil count (ANC) >1,500/mm3

- Platelet count >/= 100,000/µl

- Total bilirubin
- ALT < 2.5 x upper limit of normal ( with liver metastases) AST < 2.5 x upper limit of normal ( normal in patients with liver metastases)

- Alkaline phosphatase < 4 x upper limit of normal ( in patients with liver metastases)

- PT-INR or PTT < 1.5 x upper limit of normal

- Serum creatinine < 1.5 x upper limit of normal

- Calculated creatinine clearance of >/= 50 mL/min

Exclusion Criteria:

- NSCLC patients with predominantly squamous cell carcinoma histology

Excluded medical conditions:

- History of cardiac disease: Congestive heart failure, Active coronary artery disease
(CAD), Cardiac arrhythmias (>Grade 2 NCI-CTCAE vers. 3.0)

- Uncontrolled hypertension despite two anti-hypertensive medications

- History of HIV infection or chronic hepatitis B or C

- History of organ allograft

- Active clinically serious infections (> grade 2 NCI-CTCAE vers. 3.0)

- Patients with seizure disorder requiring medication

- Patients with evidence or history of bleeding diathesis or coagulopathy

- Patients undergoing renal dialysis

- Pulmonary hemorrhage/ bleeding event >/= CTCAE grade 2 within four weeks prior to the
first dose of the study drug

- Any other hemorrhage/ bleeding event >/= CTCAE grade 3 within four weeks prior to
the first dose of the study drug

- Thrombotic or embolic venous or arterial events such as cerebrovascular accident

- Pregnant or breast-feeding women.

- Any condition which could affect the absorption or pharmacokinetics of the study drug

- Prior treatment with other VEGF(R) inhibitors, including compounds that impact
vascularity (i.e. sunitinib, thalidomide, vandetanib, vascular disrupting agents
[VDA], VEGF-trap and other experimental agents of this class). Only bevacizumab
(Avastin) is permitted.