Inclusion Criteria:

- The patient must have histologically confirmed adenocarcinoma of the colon or rectum
that is locally-advanced or metastatic and unresectable

- The patient has at least one unidimensionally-measurable target lesion (≥ 2 cm with
conventional techniques or ≥ 1 cm with spiral computed tomography [CT] scan or
magnetic resonance imaging [MRI], as defined by Response Evaluation Criteria in Solid
Tumors [RECIST]); target lesion(s) must not lie within an irradiated area. Patients
with locally advanced rectal carcinoma who have undergone previous radiation must
have documented evidence of disease progression in the pelvis in order to participate

- The patient is age ≥ 18 years

- The patient has a life expectancy of ≥ 6 months

- The patient has an Eastern Cooperative Oncology Group Performance Status (ECOG PS)
0-1 at study entry

- The patient has adequate hematologic function, as evidenced by an absolute neutrophil
count (ANC) ≥ 1500/μL, hemoglobin ≥ 10 g/dL, and platelets

≥ 100,000/μL

- The patient has adequate hepatic function as defined by: total bilirubin

≤ 1.5 x upper limit of normal (ULN), aspartate transaminase (AST) and alanine
transaminase (ALT) ≤ 3.0 x ULN [or 5.0 x ULN in the case of liver metastases], and
serum albumin ≥ lower limit of normal institutional range (LLN) or (if < LLN) within
10% of the LLN

- The patient has adequate renal function as defined by a serum creatinine

≤ 1.5 x ULN, or creatinine clearance (measured via 24-hour urine collection)

≥ 60 mL/min

- The patient's urinary protein ≤ 1+ on dipstick or routine urinalysis ([UA]; if urine
dipstick or routine analysis is ≥ 2+, a 24-hour urine for protein must demonstrate <
1000 mg of protein in 24 hours to allow participation in the study)

- The patient must have adequate coagulation function as defined by International
Normalized Ratio (INR) ≤ 1.5 and a partial thromboplastin time (PTT)≤ 5 seconds above
the ULN. Patients on full-dose anticoagulation must be on a stable dose of oral
anticoagulant or low molecular weight (LMW) heparin and if on warfarin, must have an
INR between 2 and 3 and no active bleeding or pathological condition present that
carries a high risk of bleeding (eg, tumor involving major vessels or known varices)

- The patient has resolution to Grade ≤ 1 by the National Cancer Institute Common
Terminology Criteria for Adverse Events, Version 3 (NCI-CTCAE v 3.0) of all
clinically significant toxic effects of prior chemotherapy, surgery, radiotherapy, or
hormonal therapy with the exception of peripheral neuropathy which must have resolved
to Grade 0

- The patient agrees to use adequate contraception during the study period and for 8
weeks after the last dose of study treatment

- The patient has provided signed informed consent

Exclusion Criteria:

- The patient has received prior systemic chemotherapy for locally-advanced
unresectable or metastatic CRC. Prior adjuvant chemotherapy is allowed if disease
progression has been documented > 6 months after the end of the last cycle of
adjuvant chemotherapy or > 12 months after the end of the last cycle of adjuvant
oxaliplatin-containing regimens

- The patient has documented and/or symptomatic brain or leptomeningeal metastases

- The patient has participated in clinical studies of non-approved experimental agents
or procedures within 12 weeks of study entry

- The patient has received previous therapy with monoclonal antibodies

- The patient has received previous therapy with any agent that targets VEGF or VEGFR-2
(including multi-targeted tyrosine kinase inhibitors)

- The patient has an ongoing or active infection, symptomatic congestive heart failure,
unstable angina pectoris, symptomatic or poorly controlled cardiac arrhythmia,
psychiatric illness/social situations, or any other serious uncontrolled medical
disorders in the opinion of the investigator

- The patient is on chronic non-topical corticosteroid treatment for > 6 months at
doses > 10 mg/day of prednisolone or equivalent before study entry, which in the
opinion of the investigator could compromise the patient or the study

- The patient has a known dihydropyrimidine dehydrogenase (DPD) deficiency

- The patient has a known allergy to any of the treatment components

- The patient has an acute or subacute intestinal obstruction

- The patient has uncontrolled or poorly controlled hypertension on a standard regimen
of anti-hypertensive therapy

- The patient has a concurrent active malignancy other than adequately treated
nonmelanomatous skin cancer, other noninvasive carcinoma, or in situ neoplasm. A
patient with previous history of malignancy is eligible, provided that he/she has
been disease free for > 3 years

- The patient, if female, is pregnant

- Has had prior autologous or allogeneic organ or tissue transplantation

- Has interstitial pneumonia or interstitial fibrosis of the lung, which in the opinion
of the investigator could compromise the patient or the study

- Has pleural effusion or ascites that causes > Grade 1 dyspnea

- Has psychological, familial, sociological, or geographical conditions which do not
permit adequate study follow-up, compliance with the protocol, or signature of
Informed Consent

- Has undergone major surgery within 28 days prior to the first dose of study
medication, or subcutaneous venous access device placement within 7 days prior to the
first dose of study medication