Inclusion Criteria:

- 18 years of age or older

- Radiographically measurable disease on contrast-enhanced MRI or CT images

- Karnofsky Performance status of 60 or greater

- Life expectancy of at least 3 months

- Histologically confirmed diagnosis of recurrent or progressive intracranial
meningioma(s). This includes benign, atypical, or malignant meningioma; patients
with neurofibromatosis type 1 or 2 may participate. Participants without
histological confirmation but a classic radiographic picture of meningioma may also
enroll. Patients with neurofibromatosis type 2 and a classic radiographic picture of
meningioma may also enroll without histological confirmation

- At least ten unstained standard (4-5 micron) paraffin slides for
immunohistochemistry. Participants who have not had a surgical procedure are exempt
from this requirement

- Unequivocal evidence for tumor progression by MRI (or CT scan if MRI is
contraindicated)

- MRI or CT must be performed within 14 days of registration

- Patients with malignant meningiomas who require corticosteroids must be on a stable
dose for at least 5 days prior to baseline imaging.

- For patients who have been treated with external beam radiation, interstitial
brachytherapy, or radiosurgery, an interval of 4 or more weeks must have elapses from
the completion of radiation therapy to study drug administration, and there must be
evidence of tumor progression.

- There is no limit on the number of prior therapies

Exclusion Criteria:

- Any cytotoxic chemotherapy, radiation, immunotherapy, or experimental therapy within
4 weeks prior to study drug administration

- Prior therapy with somatostatin, andy somatostatin analogue, or any other hormonal
treatment prescribed for the purpose of treating meningioma

- Major surgery within 4 weeks prior to study drug administration

- Malabsorption syndrome, short bowel or chologenic diarrhea not controlled by specific
therapeutic means

- Poorly controlled diabetes mellitus

- Symptomatic cholelithiasis

- Congestive heart failure, unstable angina, sustained ventricular tachycardia,
ventricular fibrillation, clinically significant bradycardia, advanced heart block or
a history of acute myocardial infarction within the six months preceding enrollment

- QTc > 450 msec

- Risk factors for Torsades de Pointes such as hypokalemia (< 3.5 mmol/L) not corrected
by treatment, hypomagnesemia (< 0.7 mmol/L or < 1.6 mg/dL) not corrected by
treatment, cardiac failure, clinically significant/symptomatic bradycardia, or
high-grade AV block

- Concomitant disease(s) that could prolong QT such as autonomic neuropathy (caused by
diabetes, or Parkinson's disease), HIV, cirrhosis, uncontrolled hypothyroidism or
cardiac failure

- Concomitant medication(s) known to increase the QT interval within 4 weeks prior to
study drug administration

- Liver disease such as cirrhosis, chronic active hepatitis or chronic persistent
hepatitis with serum bilirubin > 2x ULN, serum albumin < 0.67 LLN, or ALT or AST more
than 2 x ULN

- Any other primary malignancy within the past 3 years (with the exception of basal
cell carcinoma or carcinoma in situ of the cervix)

- Active or suspected acute or chronic, uncontrolled infection or any history of
immunocompromise, including any positive HIV test result

- Abnormal coagulation studies (PT or PTT elevated by 30% above normal limits)

- Use of anticoagulant medications (not including anti-platelet medications)

- Lab values as specified in the protocol

- Any current or prior medical condition that may interfere with the conduct of the
study or the evaluation of its results in the opinion of the investigator

- Pregnancy or lactation, or failure to practice a medically acceptable method of birth
control

- History of alcohol or drug abuse in the 6 month period before study enrollment

- Participation in any clinical investigation with an investigational drug within 1
month prior to study drug administration

- Known hypersensitivity to somatostatin analogues or any component of the pasireotide
or octreotide LAR os s.c. formulations