Inclusion Criteria:

- Histologically confirmed FL grade I-II according to the REAL/WHO classification (from
initial diagnosis made prior to starting FMR therapy);

- FLIPI 3 or more

- Central pathology review confirming the FL grade I-II diagnosis and CD20 positivity,
and no evidence/evidence with an infiltration <25% of FL in bone marrow;

- The first part of the treatment of FL must have been 4 cycles of standard FM
chemotherapy (fludarabine 25 mg/m2/day on days 1 to 3 and mitoxantrone 10 mg/m2 on
day 1) in combination with rituximab (375 mg/m2); Complete remission (CR),
unconfirmed complete remission (CRu), partial response, and non-responder according
to the International Workshop Response Criteria for NHL described by Cheson et al
after four cycles of FMR. CT scans of the neck, thorax, abdomen, and pelvis and PET
total body must have been performed within 3 weeks after the last dose of the last
course of FMR;

- Patients 18-years-of-age or older at time of accrual;

- WHO performance status (PS) of 0 to 2 within 1 week of accrual;

- Absolute neutrophil count (ANC) more than 1.5 x 109/L within 1 week of accrual;

- Hemoglobin (Hgb) more than10 g/dL within 1 week of accrual;

- Platelets more than 150 x 109/L within 1 week of accrual.

- Written informed consent obtained according to local guidelines

Exclusion Criteria:

- Presence of any other malignancy or history of prior malignancy except non-melanoma
skin tumors or stage 0 (in situ) cervical carcinoma;

- Prior radioimmunotherapy, radiation therapy, or any other NHL therapy;

- Presence of gastric, central nervous system (CNS), or testicular lymphoma at first
diagnosis;

- Histological transformation of low-grade NHL;

- Known seropositivity for hepatitis C virus (HCV) or hepatitis B surface antigen
(HbsAg);

- Known history of HIV infection;

- Abnormal liver function: total bilirubin > 1.5 x ULN or ALT > 2.5 x ULN within 1 week
of accrual;

- Abnormal renal function: serum creatinine > 2.0 x ULN within 1 week of accrual;

- Known hypersensitivity to murine or chimeric antibodies or proteins;

- G-CSF or GM-CSF therapy within two weeks (or four weeks if pegylated) prior to
screening laboratory sampling;

- Concurrent severe and/or uncontrolled medical disease (e.g., uncontrolled diabetes,
congestive heart failure, myocardial infarction within 6 months of study, unstable
and uncontrolled hypertension, chronic renal disease, or active uncontrolled
infection) which could compromise participation in the study;

- Male and female patients of child-bearing potential unwilling to practice effective
contraception during the study and unwilling or unable to continue contraception for
12 months after their last dose of study treatment;

- Female patients who are pregnant or are currently breastfeeding;

- Treatment with investigational drugs less than 4 weeks before the planned Day 1 or
nonrecovery from the toxic effects of such therapy;

- Surgery less than 4 weeks before the planned Day 1 or nonrecovery from the side
effects of such surgery;

- Concurrent corticosteroid use for any reason except as premedication in case of known
or suspected allergies to contrast media or as premedication for potential side
effects of rituximab treatment;

- Unwillingness or inability to comply with the protocol.