Proteomic Approach Using Matrix-assisted Laser Desorption/Ionization Tandem Time-of-flight (MALDI-TOF/TOF) of Tumor Response in Rectal Carcinoma After Radiochemotherapy
Good or bad responders to preoperative radiochemotherapy for locally-advanced rectal
adenocarcinoma cannot be anticipated before pathological assessment of rectal specimen. The
purpose of this prospective monocentric study is to look for early seric biomarkers
predictive of tumor response (good and bad responders) in patients treated by preoperative
radiochemotherapy (45 Gy) for rectal adenocarcinoma using a proteomic approach. All patients
with locally-advanced rectal adenocarcinoma will be enrolled. Sequential samples of sera
will be collected before, during preoperative treatment and before surgery, and analysed
using a MALDI-TOF-TOF method. Proteomic analysis will be correlated to pathological response
in order to identify potential early biomarkers of tumor response.
Observational
Observational Model: Cohort, Time Perspective: Prospective
differential expression of early seric biomarkers between good and bad responders.
at inclusion and 24-48h after starting radiochemotherapy
No
Anne RULLIER, MD
Principal Investigator
University Hospital Bordeaux, France
France: French Data Protection Authority
CHUBX - 2008/25
NCT00855946
May 2009
May 2012
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