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Aerobic and Resistance Exercise for Cancer Treatment-Related Fatigue


N/A
21 Years
N/A
Open (Enrolling)
Female
Fatigue

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Trial Information

Aerobic and Resistance Exercise for Cancer Treatment-Related Fatigue


Fatigue is a frequently reported side effect of cancer treatment. Fatigue related to cancer
and its treatment is different from fatigue occurring in other situations and its specific
causes have not been identified. Exercise may or may not improve this type of fatigue. The
purpose of this study is to examine how cancer treatments impact normal lifestyle physical
activity patterns and participation in physical activity, as well as the ability of a
walking and progressive resistance exercise program to reduce cancer-related fatigue in
breast cancer patients. This study also examines if the walking and progressive resistance
exercise program improves other factors such as quality of life, depression, anxiety,
ability to sleep, self esteem, cardiovascular fitness, energy expenditure, muscular
strength, muscle mass, and immune function (as measured by inflammatory cytokines).


Inclusion Criteria:



- Have a primary diagnosis of breast cancer,

- Have a functional capacity rating of 60 or greater on the Karnofsky Performance
Scale, when assessed by the oncologist (or physician's designee)

- Be breast cancer survivor(e.g., surgery, radiation therapy, chemotherapy, hormone
therapy). Have a life expectancy of >1 year as determined by the patient's
oncologist.

- Have the approval of their treating physician, study physician(or physician's
designee) to participate in sub-maximal physiological fitness testing and a low to
moderate home-based walking and progressive resistance exercise program.

- Be able to read English.

- Be 21 years of age or older.

- Give informed consent.

Exclusion Criteria:

- Have bone metastases that preclude participation in an exercise program either due to
symptoms such as pain or location of bone metastasis.

- Have physical limitations (i.e. cardiorespiratory, orthopedic, central nervous
system) that contraindicate participation in sub-maximal physiological fitness
testing, or a low to moderate home-based walking and progressive resistance program,
as assessed by the PAR-Q and radiation oncologist (or physician's designee)

- Be identified as in the Active or Maintenance Stage of exercise behavior as assessed
by the 1-item Exercise Stages of Change Short Form.

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Supportive Care

Outcome Measure:

Cancer-related fatigue

Outcome Time Frame:

4.5 months

Safety Issue:

No

Principal Investigator

Karen Mustian, Ph.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

James P. Wilmot Cancer Center, University of Rochester

Authority:

United States: Institutional Review Board

Study ID:

8029NCI

NCT ID:

NCT00851812

Start Date:

May 2007

Completion Date:

April 2015

Related Keywords:

  • Fatigue
  • Exercise
  • Breast cancer
  • fatigue
  • Breast Neoplasms
  • Fatigue

Name

Location

James P. Wilmot Cancer Center, University of RochesterRochester, New York  14642