An Initiative for Molecular Profiling in Advanced Cancer Therapy (IMPACT) Trial. A Molecular Profile-Based Study in Patients With Advanced Cancer Treated in the Investigational Cancer Therapeutics Program
The prognosis of patients with advanced metastatic malignancies is poor, and their median
survival, irrespective of diagnosis, is approximately 8.8 months (95% confidence interval,
7.4 to 10.9 months). In recent years there has been increased interest in novel agents.
Elucidating the molecular basis of advanced cancer will lead to the development of
potentially curative strategies for these diseases aimed at the specific molecular and
genetic aberrations characteristic of specific tumors.
This study is a molecular profiling analyses of the patients' stored samples and will not
involve more than minimal risk to the subjects. Subjects are at no more than minimal risk
because only leftover blood, tissue, and patient data will be used for this study, and all
patient data will be kept confidential.
Observational Model: Case-Only, Time Perspective: Retrospective
Establish a program for the molecular profiling of patients with advanced cancer.
Apostolia M. Tsimberidou, MD, PHD
UT MD Anderson Cancer Center
United States: Institutional Review Board
|UT MD Anderson Cancer Center||Houston, Texas 77030|