Inclusion Criteria:

- adults aged between 18 and 70 years

- must have operable grade II, III or IV glioma, recurrent high grade glioma or brain
metastases

- KPS >= 70%

- must have the understanding and ability to sign an informed consent document

- must have adequate liver and kidney function

- be male or non-pregnant, non-lactating females

- patients who are fertile must agree to use an effective method of contraception
during participation in the study

- the following laboratory results : absolute neutrophil count >= 1500 cells/µl,
platelet count >= 100000 cells/µl, SGOT <= 2.5 x ULN, serum creatinine <= 1.5 x ULN.

Exclusion Criteria:

- contraindication to surgery

- concomitant radio-, chemo-, or immunotherapy

- history of significant dementia

- known diagnosis of Human Immunodeficiency Virus (HIV) infection

- patient with hepatitis B or C