Inclusion Criteria:

- Diagnosis of Prostate Cancer

- Castrate Resistant Disease with rising PSA despite continuous treatment with
orchiectomy or a LHRH agonist

- Rising PSA after treatment and withdrawal of anti-androgen

- Serum Testosterone <50ng/mL

- Normal organ function per laboratory tests

Exclusion Criteria:

- No evidence of immunosuppression or on treatment with immunosuppressive agents

- Cannot have discontinued LHRH agonist treatment (if not previously treated by
orchiectomy) within 6 months prior to study entry

- Must not be concurrently taking other medications or supplements with known hormonal
effects (other than the LHRH agonist noted above).

- Cannot have any evidence for metastatic disease on bone or CT scan

- Unable or unwilling to undergo two leukapheresis procedure