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Motion Correction of Positron Emission Tomography (PET) Data Using Amplitude Gating

18 Years
Not Enrolling
Lung Cancer

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Trial Information

Motion Correction of Positron Emission Tomography (PET) Data Using Amplitude Gating

Routine PET/CT scans are taken while patients are breathing normally. The motions made by
breathing can reduce the image quality of the scan. Minimizing the effects of this motion
by taking the images and processing the scans differently may improve the image quality.

The PET/CT Scan:

If you agree to take part in this study, an elastic belt will be placed around your lower
chest/upper abdomen before your routine PET/CT scan. This belt is used to track your
breathing motion. This information will be used to help process the scan.

Your PET/CT scan will be performed as usual. During the scan, researchers will focus on
your lower chest/upper abdomen (areas that experience breathing motion). Having to focus on
this area might extend the scan by up to 10 minutes.

The additional scan time will not increase your radiation exposure since only PET scanning
will be performed.

Length of Study:

Your participation on this study will be complete when your scheduled PET/CT scan is

This is an investigational study. The imaging focused on your lower chest/upper abdomen
during the scan is investigational.

Up to 26 patients will take part in this study. All will be enrolled at M. D. Anderson.

Inclusion Criteria:

1. Patients with lung or liver lesions measuring 0.5-2cm in diameter will be considered.

2. Patients that are scheduled to be imaged in the PET/CT suite at the Mays Building
will only be considered.

Exclusion Criteria:

1. Pediatric patients (younger than 18 years) will be excluded.

2. Patients that cannot tolerate being scanned for an additional 10 minutes with arms
above their head will be excluded.

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

Mean Difference Between Gated + Ungated PET/CT Scans

Outcome Time Frame:

Scheduled PET/CT scans extended by 10 minutes

Safety Issue:


Principal Investigator

Osama R Mawlawi, PHD

Investigator Role:

Principal Investigator

Investigator Affiliation:

UT MD Anderson Cancer Center


United States: Institutional Review Board

Study ID:




Start Date:

March 2009

Completion Date:

Related Keywords:

  • Lung Cancer
  • Lung
  • Lung Cancer
  • Non-small cell Lung Cancer
  • Motion Correction
  • PET/CT Scan
  • PET
  • Positron Emission Tomography
  • CT
  • Computed Tomography
  • Amplitude Gating
  • Lung Neoplasms



UT MD Anderson Cancer Center Houston, Texas  77030