Inclusion Criteria:

- Patients affiliated to a social security reimbursement system

- Adults (men or women) aged between 18 and 65 years

- Negative test for pregnancy

- ECOG 0-1 or Karnofsky Index ≥ 70%

- Availability of an HLA-identical sibling donor, or an HLA-matched unrelated donor
(10/10 HLA compatibility in A, B, C, DRB1, DQB1 (a single allelic mismatch at the
level of Cw can be accepted)

- Life expectancy > 6 months

- Signed informed consent

- Diagnosis of an hematological malignancy that is considered to be eligible for an
allogeneic stem cell transplantation

Exclusion Criteria:

- Pregnant woman or not willing to take effective contraception

- Classical contra-indications to the allogeneic stem cell transplantation procedure

- Any contra-indication to the use of the drugs contained within the conditioning
regimen according to the summary of product characteristics

- Patients aged < 50 years and deemed to be eligible for a "standard" or conventional
myeloablative conditioning regimen

- An HLA-matched sibling donor who has a contra-indication for stem cell mobilization
and collection

- History of uncontrolled psychiatric condition

- Patients who have participated to another trial testing an experimental drug within
one month prior to inclusion in this protocol.