Inclusion Criteria:

- age > 18 years and ≤ 40 years

- diffuse POLYMYOMATOSIS or recurrent POLYMYOMATOSIS after surgery requiring multiple
myomectomies by laparotomies i.e. at least 3 fibroids of significant diameter
(including 1 fibroid longer than 3 cm using ultrasound)

- symptomatic fibroids causing chronic pelvic pain and/or pelvic pressure and/or
haemorrhage genital

- immediate desire for future pregnancy without indication for assisted medical
reproduction (bilateral hydrosalpinx, male infertility)

- covered by french health insurance

- patient knowing to read and understanding French

- patient signing of an informed consent form, after appropriate information has been
provided

Exclusion Criteria:

- evolutionary pregnancy

- medical emergency situation

- Contraindication by the surgery or Uterine Artery Embolisation : allergy, severe
renal failure, immune system deficiency or anesthesic

- age > 40 years

- fibroids accessible to laparoscopies removal (less than 3 fibroids measuring 3 cm or
1 dominant fibroid measuring 8 cm) or hysteroscopies resection (submucous fibroids
type 0 or I according to DONNEZ'S classification) or abdominal myomectomy indicated
by large volume single intramural or subserosal fibroid

- abnormal hormonal profile at day 3 of the cycle evaluated during a pluridisciplinary
consultation

- Male infertility requiring management for assisted medically reproduction (systematic

- spermograms will be obtained in routinely)

- amenorrhea

- visible hydrosalpinx for ultrasonography or MRI

- no explored an adnexal mass

- diffuse adenomyosis as the dominant disease

- no affiliation of social coverage

- bad comprehension of french preventing an informed consent form or information of
self questionnaires

- social situation posing to difficulty of follow-up