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Comparison of Skin Carotenoid Levels Between Subjects With History of Cutaneous Squamous Cell Carcinoma and Subjects With History of Basal Cell Carcinoma Versus a Control Group


N/A
50 Years
75 Years
Not Enrolling
Both
Skin Cancer, Basal Cell Carcinoma, Squamous Cell Carcinoma

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Trial Information

Comparison of Skin Carotenoid Levels Between Subjects With History of Cutaneous Squamous Cell Carcinoma and Subjects With History of Basal Cell Carcinoma Versus a Control Group


There has been experimental and clinical research evaluating association of different
carotenoids and incidence of malignancies, including Non- Melanoma Skin Cancer (NMSC). An
easy and inexpensive way to determine which subjects would benefit from supplementation with
carotenoids or retinoids could be the measurement of skin carotenoid levels.The least
invasive way to perform it is through Raman spectroscopy which is a technique that uses a
laser light that can be used to quantify carotenoids on the skin. We will compare the skin
carotenoid levels of subjects with previous history of SCC or BCC and subjects without
history of previous NMSC.


Inclusion Criteria:



- Subjects between 50 and 75 years old without history of previous SCC or BCC.

- Fitzpatrick skin types I-IV.

- Willing and able to understand and sign informed consent.

- Able to complete study and comply with study procedures

Exclusion Criteria:

- Regular ingestion of supplements containing carotenoids or vitamin A in the past 4
weeks.

- Use of topical retinoids in the past 4 weeks.

- Treatment with systemic retinoids in the past 6 months.

- Dermatologic conditions that require the use of interfering topical or systemic
therapy or that might interfere with study assessments such as, but not limited to,
palmar psoriasis, hand dermatitis or palmo-plantar keratoderma.

- Previous history of psoriasis.

- Clinically significant abnormal findings or conditions, which might, in the opinion
of the Principal Investigator, interfere with study evaluations or pose a risk to
subject safety during the study.

- Subjects who are known to be pregnant or planning a pregnancy.

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Cross-Sectional

Outcome Measure:

Skin Carotenoid Levels in Subjects With History of Squamous Cell Carcinoma Versus Control Subjects

Outcome Description:

Mean carotenoid levels in subjects with a history of squamous cell carcinoma were compared to mean carotenoid levels in control subjects without a history of nonmelanoma skin cancer.

Outcome Time Frame:

baseline

Safety Issue:

No

Principal Investigator

Alexandra B Kimball, MD, MPH

Investigator Role:

Principal Investigator

Investigator Affiliation:

Massachusetts General Hospital

Authority:

United States: Institutional Review Board

Study ID:

2008-P-002240

NCT ID:

NCT00836342

Start Date:

February 2009

Completion Date:

January 2012

Related Keywords:

  • Skin Cancer
  • Basal Cell Carcinoma
  • Squamous Cell Carcinoma
  • Non-melanoma skin cancer
  • Basal cell carcinoma
  • Squamous cell carcinoma
  • Carcinoma
  • Skin Neoplasms
  • Carcinoma, Basal Cell
  • Carcinoma, Squamous Cell

Name

Location

Clinical Unit for Research Trials in Skin - MGHBoston, Massachusetts  02114