A Cohort Study on Prediction of Malignant Transformation of Oral Epithelial Dysplasia by p16 Methylation
- Background: Identification of malignant potential of oral epithelial dysplasia (OED) is
virtually impossible on histopathological grounds alone. Inactivation of p16 gene by
CpG methylation is an early frequent event during oral carcinogenesis. To investigate
the predictive value of p16 methylation on malignant potential in OED, we carried out
the prospective cohort study.
- Methods: 101 patients with histologically confirmed mild or moderate OED were included
in the present study. Baseline information of p16 methylation status of the OED lesions
from 93 cases was obtained by methylation-specific PCR. Progression of the OEDs lesions
was examined in 78 cases histologically during the 45.8 months double-blind followup
survey (78/93). The association between p16 methylation and progression of OED was
analyzed with SPSS13.0 software. All P-values were two-sided.
Observational
Observational Model: Cohort, Time Perspective: Prospective
The Number of Participants With Both Clinical and Histological Evidence of Malignant Transformation of Oral Epithelial Dysplasia
from 3 months to 124 months
No
Dajun Deng, MD
Study Director
Beijing Cancer Hospital/ Institue, Peking University School of Oncology
China: Ethics Committee
CPDHS-434
NCT00835341
March 2005
October 2008
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