Trial Information

Phase I-II Trial of Hypofractionated Conformal Proton Beam Radiation Therapy for Favorable-risk Prostate Cancer

Radiation therapy has a long and established role in the curative treatment of
organ-confined prostate cancer. However, the optimal radiation dose and treatment schedule
remain unknown. The use of hypofractionation has a long and generally successful history in
conformal proton beam therapy. Several reports detailing the efficacy and safety of
hypofractionated conformal radiation therapy (with x-rays) of prostate cancer can be found
in the literature. Hypofractionated conformal proton beam radiation therapy has become our
institutional routine for the treatment of numerous solid tumors. The purpose of this study
is to determine if a shortened overall treatment schedule will result in equivalent tumor
control rates and no increased side effects as compared to our current institutional
standard treatment of an equivalent dose given over a longer period of time.