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RELATIONSHIP OF POLYMORPHISMS AND MUTATIONS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND TYROSINE KINASE INHIBITORS RESPONSIVENESS IN NON-SMALL-CELL LUNG CANCER PATIENT


N/A
18 Years
N/A
Open (Enrolling)
Both
Non-Small-Cell Lung Cancer

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Trial Information

RELATIONSHIP OF POLYMORPHISMS AND MUTATIONS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND TYROSINE KINASE INHIBITORS RESPONSIVENESS IN NON-SMALL-CELL LUNG CANCER PATIENT


DNA will be isolated from blood samples or paraffin-embedded tumor specimens and than a
mutation analysis and SNPs genotyping will be done.


Inclusion Criteria:



- Availability of tumor tissue or blood samples.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Retrospective

Outcome Measure:

to evaluate the presence of EGFR- and AKT-DNA polymorphisms.

Outcome Time Frame:

At the end of enrollment

Safety Issue:

No

Principal Investigator

Armando Santoro, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Istituto Clinico Humanitas

Authority:

Italy: Ministry of Health

Study ID:

ONC/OSS-02/2008

NCT ID:

NCT00831454

Start Date:

September 2008

Completion Date:

October 2008

Related Keywords:

  • Non-Small-Cell Lung Cancer
  • Carcinoma, Non-Small-Cell Lung
  • Lung Neoplasms

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