Inclusion Criteria:

- Histologically proven resectable adenocarcinoma of the lower oesophagus and
gastric-oesophageal junction

- Tumour stage: T2-3 N0-1 M0, as assessed by endoscopic ultrasound and CT-scan of
thorax and abdomen and ultrasound neck region. For the patients treated in this study
the gastro-oesophageal junctional tumors will be staged as oesophageal tumors with
respect to their lymphnode metastases.

- Age >18y and written informed consent after at least 4 days of deliberation time from
the moment the patient information has been given and has been explained.

- Weight loss < 10% in 0.5 yr

- WHO performance status 0-1

- No prior radiotherapy or chemotherapy for the adenocarcinoma of the oesophagus

Exclusion Criteria:

- Previous malignancy other than basal cell carcinoma of the skin or local resection
for cervical carcinoma in situ.

- Inadequate organ function as defined by:

- Inadequate haematology (Hb < 5,5 mmol/L (red blood cell transfusions are allowed to
increase the Hb at the discretion of the investigator) - neutrophils < 1,5 109/L
-platelets <100*109/L),

- Liver enzyme elevation (bili > 1,5*ULN - ASAT > 2,5*ULN - ALAT > 2,5*ULN) or

- Impaired renal function (creatinine clearance by cockcroft < 60 cc/min)

- Proteinuria >1,0gr/24hr

- Tumour stage: M1a and/or tumour length > 8 cm and/or > 5 cm radially

- Major surgery within 4 weeks prior to the start of study treatment

- Bleeding disorder

- Known allergy to one of the study drugs used

- Use of any substance known to interfere with the chemotherapy clearance

- Previous radiotherapy to the chest

- Significant concomitant diseases preventing the safe administration of study drugs or
likely to interfere with study assessments

- Uncontrolled angina pectoris; cardiac failure or clinically significant arrhythmias

- Continuous use of immunosuppressive agents

- Concurrent use of the antiviral agent sorivudine or chemically related analogues,
such as brivudine

- Prior exposure to anti-EGFR targeting agents.

- Hearing loss > 25 dB under normal

- Neurotoxicity > CTC grade 1

- Pregnancy or breast feeding

- Patients (M/F) with reproductive potential not implementing adequate contraceptive
measures