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A Randomized Controlled Trial of Treatment of Portal Vein Tumor Thrombus After Hepatocellular Carcinoma Resection

18 Years
70 Years
Open (Enrolling)
Hepatocellular Carcinoma

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Trial Information

A Randomized Controlled Trial of Treatment of Portal Vein Tumor Thrombus After Hepatocellular Carcinoma Resection

Hepatectomy is still the treatment of choice for hepatocellular carcinoma, but the prognosis
is not agreeable. Part of the patients may present portal vein tumor thrombus (PVTT) after
resection. PVTT might further increase the pressure of portal vein and lead to upper
gastrointestinal bleeding and worsening of hypersplenism which will endanger the life of the
patients. PVTT also plays the centre role of recurrence and metastasis of HCC. There is no
standard treatment available now for PVTT yet. TACE is mostly often used to treat the PVTT.
We aim to compare the effects of TACE and TACE plus laser ablation for treating patients
with PVTT.

Inclusion Criteria:

1. PVTT after liver resection was diagnosed with at least two types of imaging findings,
such as CT, MRI or color doplor findings.

2. The functions of the kidney, heart and lung and the routine test of the blood are in
good condition.

3. The liver function is of grade A or B in Child-Pugh classification.

4. The patient is eligible of the trial and will show consent to the test.

Exclusion Criteria:

1. any of the parameters. WBC less than 2000/ml, Hb less than 90g/L or PLT less than

2. disfunction of the heart, lung, kidney, or brain.

3. any other disease might affect the trial .

4. the patients would not sign the consent to the trial.

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

overall survival

Outcome Time Frame:


Safety Issue:


Principal Investigator

shen feng, M.D

Investigator Role:

Study Chair

Investigator Affiliation:

Eastern Hepatobiliary Surgery Hospital Affiliated to Second Military Medical University


China: Ministry of Health

Study ID:




Start Date:

December 2008

Completion Date:

December 2010

Related Keywords:

  • Hepatocellular Carcinoma
  • hepatocellular carcinoma
  • Portal vein tumor thrombus
  • laser ablation
  • Carcinoma
  • Thrombosis
  • Carcinoma, Hepatocellular