Inclusion Criteria:

1. Identify patients with PLC in accordance with the clinical diagnostic criteria of
PLC.Patients with PLC shall be diagnosed with or without pathology. It is not
appropriate to perform liver resection operation.

2. serum positive HBsAg≥6 months.

3. Criteria of liver function: Child A or B level, serum total bilirubin ≤ 1.5 times the
upper limit of normal value, alanine aminotransferase and aspartate aminotransferase
≤ 10 times the upper limit of normal value.

4. hemoglobin≥8.5g/dl, PT-INR≤2.3 or PT>6 seconds of normal value.

5. No dysfunction in major organs; Blood routine, kidney function, cardiac function and
lung function are basically normal.

6. Patients who can understand this trial, male or female, aged 18-70 voluntarily
participate in clinical trials and have signed information consent.

Exclusion Criteria:

1. Patients with apparent cardiac, pulmonary, cerebric and renal dysfunction, which may
affect the treatment of liver cancer.

2. Patients with other diseases which may affect the treatment mentioned here.

3. Patients with medical history of other malignant tumors.

4. Subjects participating in other clinical trials.

5. Women in pregnancy and breast-feeding.