Inclusion Criteria:

- confirmed and active CLL requiring treatment

- at least one previous treatment for CLL and having achieved a complete or partial
remission/response but after a period of 6 or more months, shows evidence of disease
progression

- fully active at a minimum or fully capable of selfcare and up and about more than 50%
of waking hours

- age 18yrs or older

- signed written informed consent

Exclusion Criteria:

- diagnosis of refractory CLL (failure to achieve a complete or partial
remission/response or disease progression within 6 months of last anti-CLL treatment

- abnormal/inadequate blood values, liver and kidney function

- certain heart problems, serious significant diseases, AIHA, other current cancers or
within the last 5 years

- active or chronic infections

- use of drugs to suppress allergic or inflammatory responses (glucocorticoids)

- CLL transformation

- CLL central nervous system involvement

- current participation in other clinical study

- inability to comply with the protocol activities

- lactating or pregnant women or female patients of child-bearing potential (or male
patients with such partners) not willing to use adequate contraception