Inclusion Criteria:

- Age 40 to 80 years old

- Language spoken: Finnish or Swedish

- Performance status: Karnofsky score 70 or better or WHO performance status 2 or
better

- earlier diagnosed (histologically confirmed) colorectal cancer with discovered
metastases at operation

- Earlier diagnosed and treated colorectal cancer with discovered recurrence in the
follow up

- Mental status: Patients must be able to understand the meaning of the study

- Informed consent: The patient must sign the appropriate Ethical Committee (EC)
approved informed consent documents in the presence of the designated staff

Exclusion Criteria:

- Prior medical history: Patient must have no history of serious cardiovascular, liver
or kidney disease

- Vulnerable study subjects such as described in Finnish law concerning clinical
studies (disabled, children, pregnant or breast-feeding women, prisoners) will not be
included.