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18 Years
Not Enrolling
Gastric Cancer Patients Treated by Subtotal Gastrectomy

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Trial Information

The below is the items to be included in the study.

- diet evaluation: standard three-day diet evaluation table (Dept. of Nutrition)

- body weight and height: BMI .

- ELISA for plasma ghrelin, leptin, insulin, CCK, PYY: whole blood 5 ml in EDTA tube
(sampling time: during fasting, around 8 AM-9 AM if possible)

- two biopsy specimen: the same site. Fundus. One for ELISA and one for IHC

- ELISA for tissue ghrelin: frozen in liquid nitrogen

- immunohistochemistry for ghrelin producing cell hyperplasia, Paraffin block cutting for

Inclusion Criteria:

- patients with informed consent

- gastric cancer patients treated by subtotal gastrectomy (without chemotherapy or
radiation therapy) : Actually the differentiation of EGC or AGC depend on the depth
of invasion. Therefore if the patients are not cachetic because of metastasis or
tumor burden, there is no need toe exclude the AGC patients from the study.

Exclusion Criteria:

- patients with chemotherapy or radiation therapy diabetes mellitus: It has been
reported that plasma ghrelin is influenced by the insulin. Thus a history of diabetes
exclude the enrollment of the protocol.

Type of Study:


Study Design:

Time Perspective: Prospective

Principal Investigator

Dong-Kyu Jin, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

Samsung Medical Center, Sungkyunkwan University School of Medicine


South Korea: Institutional Review Board

Study ID:




Start Date:

January 2005

Completion Date:

July 2007

Related Keywords:

  • Gastric Cancer Patients Treated by Subtotal Gastrectomy
  • obestatin
  • ghrelin
  • stomach cancer
  • distal gastrectomy
  • Stomach Neoplasms