Gene Expression Signature and Immunohistochemical Markers Associated With Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer
Locally advanced breast cancer is a common condition in development countries. Neoadjuvant
chemotherapy gives the opportunity to identify genetic signatures associated with objective
clinical and pathological complete responses.
Patients will receive doxorubicin/cyclophosphamide with paclitaxel. Tumor samples collected
before and after chemotherapy will be analyzed.
Observational
Observational Model: Cohort, Time Perspective: Prospective
Clinical objective and pathological responses to chemotherapy
8 months
Yes
Maria Aparecida A Koike Folgueira, MD, PhD
Study Chair
Faculdade de Medicina - Universidade de São Paulo
Brazil: Ethics Committee
135/2008
NCT00820690
October 2008
September 2014
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