Inclusion Criteria:

1. Signed, informed consent

2. Confirmed malignant haematological disease or lymphoid malignancy refractory to
standard therapy or for which no standard therapy exists, including acute leukemias,
MDS, CML, CLL, CMML, multiple myeloma and Non-Hodgkin's Lymphomas/Hodgkin's disease

3. Patients shall have recovered from all acute adverse effects of prior therapies, with
the exception of alopecia and grade 1 neuropathy where recovery is not required

4. Adequate bone marrow, hepatic and renal function including the following:

1. Patients with high blast counts can be included if they can be controlled by the
use of hydroxyurea (500 mg -3,000 mg daily).

2. Total bilirubin ≤ 1.5 x upper normal limit, excluding cases where elevated
bilirubin can be attributed to Gilbert's Syndrome

3. AST (SGOT), ALT (SGPT) ≤ 2.5 x upper normal limit

4. Creatinine ≤ 1.5 x upper normal limit

5. Age ≥ 18 years

6. Performance status (PS) ≤ 2 - Eastern Cooperative Oncology Group (ECOG) scale

7. Estimated life expectancy greater than 3 months

8. Female patients with reproductive potential must have a negative serum pregnancy test
within 7 days prior to start of trial. Both women and men must agree to use a
medically acceptable method of contraception throughout the treatment period and for
3 months after discontinuation of treatment.

Exclusion Criteria:

1. Patients receiving anti-cancer therapy or use of other investigational agents within
21 days prior to trial entry (or a longer period depending on the defined
characteristics of the agents used. Bisphosphonates for bone disease and
corticosteroids are permitted provided the dose does not change during the trial.
Patients must have recovered from all transient toxicity induced by prior therapy

2. Patients with co-existing active infection, graft versus host disease or serious
concurrent illness

3. Patients who have failed to recover from or after a bone marrow transplantation or
haematopoietic stem cell transplantation

4. The following diseases are excluded: Burkitt's lymphoma, primary effusion lymphoma,
precursor B-cell lymphoblastic lymphoma, symptomatic central nervous system (CNS)
lymphoma, CML blast crisis

5. Patients with significant cardiovascular disease as defined by:

1. history of congestive heart failure requiring therapy

2. history of angina pectoris requiring treatment or myocardial infarction within 6
months prior to trial entry

3. presence of severe valvular heart disease

4. presence of an atrial or ventricular arrhythmia requiring treatment

5. Left Ventricular Ejection Fraction (LVEF) below the normal range at the study
centre

6. Uncontrolled hypertension

7. A history of abnormal QTc intervals or an average QTc interval at screening ≥450
msec

6. Any medical or other condition that in the investigator's opinion renders the patient
unsuitable for this study due to unacceptable risk

7. Psychiatric disorders or altered mental status precluding understanding of the
informed consent process and/or completion of the necessary studies

8. Gastrointestinal disorders that may interfere with absorption of the study drug

9. Patients with known brain tumours or metastases

10. More than 6 prior chemotherapy regimens

11. Patients requiring growth factor support (erythropoietin, Granulocyte/monocyte Colony
Stimulating Factor (GM/CSF), etc)

12. Patients requiring palliative radiotherapy within the last 4 weeks prior to study
entry

13. Uncontrolled hypercalcaemia (CTCAE v3 grade 2 or higher)

14. Abnormal plasma potassium or magnesium levels (Common Terminology Criteria for
Adverse Events (CTCAE) v3 grade 3 or greater) despite therapy

15. Pregnant or breast-feeding women