Inclusion Criteria:

- Patients with infertility azoospermia

- Age 18 to 35 years

- Definition of clinical and biological character of azoospermia: testicular volume
less than 10 ml and FSH more than 10 IU / l

- Normal karyotype

- Surgical exploration included in a standardized medical aid to procreation

- Testicular biopsy performed by traditional surgery

- Patient informed about the research protocol and having signed consent to conduct a
further testicular biopsy included in this study.

Exclusion Criteria:

- adults protected by law, minors

- Individuals who are not affiliated to a social security

- Subjects hospitalized for any reason other than research.

- Patients will be used to support reproductive techniques:

- Positive serology (HIV, hepatitis ...).

- Patients with karyotype anomalies and unfavourable genetic counselling