The Efficacy of Distilled Water vs Mitomycin C as a Single Dose Immediate Instillation After Transurethral Resection of Intermediate Risk, Recurrent Superficial Bladder Cancer
We plan to administer 200ml of distilled water as a single peroperative instillation and
block the catheter for 2 hours to our eligible recurrent superficial bladder cancer patients
who were in our follow-up schedule since 2002.
We plan to look over the histories of the same patients in terms of the pathologies,
recurrence patterns, the presence of peroperative intracavitary therapy after their previous
TURs for recurrences.
So we shall compare the effectiveness of MMC and distilled water on reducing the recurrences
over the same patient pool.
The patients will be scheduled for a follow-up program after TUR as;
- urine cytology
- bladder wash cytology for the probability of recurrence for 2 years to see if there is
any difference in the recurrence patterns after instillation with distilled water vs
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Caregiver), Primary Purpose: Prevention
tumor recurrence by cystoscopic examination, urine and bladder wash cytology
within two years after instillation
Zafer Kozacioglu, MD
Bozyaka Trainig and Research Hospital Urology Clinic
Turkey: Ministry of Health