Mutations in the Epidermal Growth Factor Receptor(EGFR) Gene in Non-Small Cell Lung Carcinoma (NSCLC) and the Relation to Response of Treatment With Erlotinib
Aim:
1. To establish a method for identifying the mutations in the EGFR gene in small clinical
samples from lung cancer patients.
2. In a retrospective study(n=500) relate survival to the frequency and types of mutations
in the EGFR gene in a Danish population of patients with advanced, inoperable non small
cell lung cancer (NSCLC) diagnosed prior to the introduction of treatment directed
towards EGFR.
3. In a prospective study (n=300), to identify the mutations in the EGFR gene in patients
treated with erlotinib, a tyrosine kinase inhibitor targeting the EGFR. Presence of
mutations will be related to the expression of other parts of the EGF system, to
mutations in the gene coding for K-RAS and to treatment response.
Observational
Observational Model: Case-Only, Time Perspective: Prospective
overall survival
1 year after the last patient is enrolled
No
Peter Meldgaard, PhD MD
Principal Investigator
Aarhus University Hospital
Denmark: The Regional Committee on Biomedical Research Ethics
M-20080012 (ethics committee)
NCT00815971
May 2008
May 2011
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