Interventional Study of Dexmedetomidine for Sedating Anticipated Difficult Airway Patients Undergoing Awake Fiberoptic Nasal Intubation
Case number: 60, ASA I-III oral cancer patients with limited mouth opening
Patients will be randomly allocated into three groups, Dex group received dexmedetomidine
(1.0 mcg/kg) infusion, Control group received saline, and Propofol group received 1%
Propofol administrated usng effect-site TCI.
Main outcome was evaluated by grading scores presenting conditions for nasal intubation,
post-intubation and satisfaction.
Other analysed parameters included airway obstruction, hemodynamic changes, treatment for
hemodynamics response, consumption time for intubation, amnesia level, and postoperative
adverse events. All outcome measurements were classified by scoring systems.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
grading scores presenting conditions for nasal intubation
before and after intubation
Koung-Shing Chu, Master
Kaohsiung Medical University
Taiwan: Institutional Review Board