Inclusion Criteria:

- Histologic or cytologic diagnosis pancreatic cancer

- inoperable stage II or stage III or IV disease(UICC, 1997)

- Age 18 to 75 years

- Karnofsky Performance status > 50

- Signed informed consent

Exclusion Criteria:

- Previous chemotherapy

- Cerebral metastases

- Previous malignancies in past 5 years excluding adequately treated basal or
spinocellular skin cancers and insitu cervical cancer

- Leukocytes < 4000 or neutrophils < 2000 or platelets < 100000 or hemoglobin < 10 g/dl

- Creatinine value > upper normal limit

- GOT or GPT > 2.5 times upper normal limit or bilirubin > 1.5 times upper normal limit
in absence of hepatic metastases

- Congestive heart failure, severe cardiac arrhythmias or coronary ischemic disease

- Other concurrent disease that would, in the investigator's opinion, contraindicate
the use of the study drugs

- Inability to provide informed consent

- Inability to comply with follow-up.