Randomized Phase II Study of Adjuvant Chemotherapy With 5-FU/Leucovorin vs. Oxaliplatin/5-FU/Leucovorin After Preoperative Chemoradiotherapy With Fluoropyrimidines Followed by Surgery in Patients With Locally Advanced Rectal Cancer
Preoperative chemoradiotherapy with fluoropyrimidines followed by surgery is one of the
standard treatments for patients with locally advanced rectal cancer; however, the role of
adjuvant chemotherapy is still controversial. The aim of this study is to investigate the
efficacy of adjuvant FOLFOX for rectal cancer who underwent fluoropyrimidine based
chemoradiotherapy and complete total mesorectal excision.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
disease-free survival
3 year
No
Tae Won Kim, Professor
Principal Investigator
Asan Medical Center
Korea: Food and Drug Administration
AMC-0256
NCT00807911
November 2008
August 2015
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