Inclusion Criteria:

- adult patients, >=18 years of age;

- documented inoperable, locally advanced, metastatic or recurrent non-squamous NSCLC;

- adequate liver and kidney function;

- women of childbearing potential must have a negative serum pregnancy test within 7
days of starting study treatment.

Exclusion Criteria:

- prior chemotherapy or treatment with another systemic cancer therapy;

- surgery (including open biopsy), significant traumatic injury, or radiotherapy within
the last 4 weeks prior to first dose of study treatment;

- brain metastasis or spinal cord compression;

- fertile men, and women of childbearing potential, not using adequate contraception;

- treatment with any other investigational agent, or participation in another clinical
trial, within 30 days prior to entering the study.