Inclusion Criteria:

- Locally unresectable or metastatic neuroendocrine tumor. Patients must have
confirmed low-grade or intermediate-grade neuroendocrine carcinoma. Patients with
poorly differentiated neuroendocrine carcinoma, high-grade neuroendocrine carcinoma,
adenocarcinoid, goblet cell carcinoid, and small cell carcinoma are not eligible.

- 18 years of age or older

- Minimum of four weeks since any major surgery, completion of radiation, of completion
of all prior systemic anticancer therapy.

- ECOG Performance Status 0,1, or 2.

- Life expectancy 12 weeks or more.

- Adequate bone marrow, liver and renal function as outlined in the protocol

- Negative serum pregnancy test for women of childbearing potential.

- Fasting serum cholesterol less than or equal to 300mg/dL or less than or equal to
7.75mml/L AND fasting triglycerides of less than or equal to 2.5 x ULN.

Exclusion Criteria:

- Chronic treatment with systemic steroids or another immunosuppressive agent.

- Immunization with attenuated live vaccines during study or within 1 week of study
entry.

- Uncontrolled brain or leptomeningeal metastases, including patients who continue to
require glucocorticoids for brain or leptomeningeal metastases.

- Prior or concurrent malignancy, except for the following: adequately treated basal
cell or squamous cell skin cancer, or other adequately treated in situ cancer, or any
other cancer from which the patient has been disease free for five years.

- Uncontrolled diabetes mellitus or a fasting plasma glucose of > 1.5 ULN.

- Symptomatic cholelithiasis

- Congestive heart failure, unstable angina, sustained ventricular tachycardia,
ventricular fibrillation, clinically significant bradycardia, advanced heart block or
a history of acute myocardial infarction within the six months preceding enrollment.

- Presence of active or suspected acute or chronic uncontrolled infection or with a
history of immunocompromise, including a positive HIV test result.

- Any severe and/or uncontrolled medical condition or other conditions that could
affect their participation in the study such as: severely impaired lung function;
active or uncontrolled infection/disorders; nonmalignant medical illnesses that are
uncontrolled or whose control may be jeopardized by treatment with the study therapy;
impairment of gastrointestinal function or gastrointestinal disease that may
significantly alter the absorption of RAD001; history of alcohol or drug abuse in the
6 month period prior to receiving treatment.

- Known hypersensitivity to RAD001 or other rapamycins or its excipients.

- Known hypersensitivity to somatostatin analogues or any component of the pasireotide
or octreotide LAR or s.c. formulations.

- History of non-compliance to medical regimens.

- Patients taking medication known to inhibit, induce, or be a substrate to isoenzyme
CYP3A.