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Predicting Dietary Selenium Needs to Achieve Target Blood Selenium Levels


N/A
18 Years
N/A
Not Enrolling
Both
Nutritional Requirements

Thank you

Trial Information

Predicting Dietary Selenium Needs to Achieve Target Blood Selenium Levels


Results of studies with animal tumor models and human clinical trials suggest that the
essential nutrient selenium can be anti-tumorigenic if consumed at levels greater than
nutritional requirements. If it is possible to increase plasma selenium concentrations
above 120 nanograms per milliliter with less than 200 micrograms of selenium daily, then it
is possible that supplementation can be accomplished through the use of selenium-containing
foods.


Inclusion Criteria:



- able to swallow capsules

- body mass index less than 40

Exclusion Criteria:

- Pregnancy

- Chronic liver or kidney disease

- taking medication that might affect liver and/or kidney

- blood pressure 140/90 or higher

- already taking more than 50 micrograms of selenium

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Outcome Measure:

Evaluation of effectiveness of consuming oral doses of L-selenomethionine in raising plasma selenium concentrations

Outcome Time Frame:

Baseline, and after 3, 6, 9, and 12 months of supplementation

Safety Issue:

No

Principal Investigator

Gerald F Combs, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

USDA Grand Forks Human Nutrition Research Center

Authority:

United States: Federal Government

Study ID:

GFHNRC009

NCT ID:

NCT00803699

Start Date:

November 2005

Completion Date:

September 2007

Related Keywords:

  • Nutritional Requirements
  • selenium

Name

Location

USDA Grand Forks Human Nutrition Research CenterGrand Forks, North Dakota  58202