Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically confirmed ovarian epithelial, fallopian tube, or primary peritoneal
cavity cancer

- Stage II-IV disease

- Tumor expresses 1 of the following antigens:

- NY-ESO-1 by RT-PCR or IHC

- LAGE-1 by RT-PCR

- Previously treated with initial surgery AND ≥ 1 platinum-based chemotherapy regimen

- Must have demonstrated complete response to prior front-line therapy as evidenced by
negative clinical examination, no objective evidence of disease progression by CT
scan, and serum CA-125 ≤ 35 IU/mL

- If second-look surgery was performed, patient may have either a negative or
microscopic positive second-look surgery (laparoscopy or laparotomy)

- Recurrent disease allowed provided patient completed surgery and/or chemotherapy for
recurrent disease

- Patient may have asymptomatic residual measurable disease by physical
examination and/or CT scan and/or elevated CA-125 or may be in complete clinical
remission

- No CNS metastases

PATIENT CHARACTERISTICS:

- Karnofsky performance status ≥ 70%

- Life expectancy ≥ 6 months

- ANC ≥ 1,500/mm^3

- WBC ≥ 5,000/mm^3

- Platelet count ≥ 100,000/mm^3

- Hemoglobin ≥ 10 g/dL

- Serum creatinine ≤ 2 mg/dL

- Serum bilirubin ≤ 2 mg/dL

- No history of autoimmune disease (e.g., thyroiditis or lupus), except vitiligo

- No known immunodeficiency or HIV positivity

- No known allergy or history of life threatening reaction to sargramostim (GM-CSF)

- No known history of allergies to eggs, neomycin, or bovine products

- No history of severe allergic reactions to vaccines or unknown allergens

- None of the following cardiovascular conditions:

- Myocardial infarction

- Angina

- Congestive heart failure

- Cardiomyopathy

- Stroke or transient ischemic attack

- Chest pain or shortness of breath with activity

- Other heart conditions being treated by a doctor

- No other serious illness (e.g., serious infections requiring antibiotics or bleeding
disorders)

- No other malignancy within the past 3 years, except previously treated nonmelanoma
skin cancer or carcinoma in situ of the cervix

- No mental impairment that may compromise the ability to give informed consent and
comply with study requirements

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- Recovered from prior surgery

- More than 4 weeks since prior and no concurrent chemotherapy (6 weeks for
nitrosoureas), radiotherapy, immunotherapy, or other anticancer therapy

- Concurrent hormonal or hormonal-related anticancer therapy allowed

- More than 4 weeks since prior participation in another clinical trial involving an
investigational agent

- No prior NY-ESO-1 vaccine therapy

- No concurrent systemic corticosteroids, antihistamines, non-steroidal
anti-inflammatory drugs, or other immunosuppressants

- Concurrent low-dose aspirin (≤ 100 mg/day) or specific COX-2 inhibitors allowed