Pilot Study to Validate Metallic Markers for Image Guided Radiation Therapy for Breast Cancer Treatment
In order to validate metallic marker placement and stability, patients will have the
internal metallic markers placed at the time of their last breast surgery (either lumpectomy
or re-excision for margins) by the surgeon and are permanent. They will undergo routine 3D
CT-based treatment planning and will receive routine radiation treatment to the whole breast
or partial breast as determined by the treating physician. Daily images of the breast will
be obtained throughout treatment using the online portal imaging system. These images will
be analyzed for the daily position of the metallic markers and compared across the entire
course of treatment to determine the stability of metallic markers placement and to assess
their efficacy as positioning devices for image guided radiation therapy.
Observational Model: Cohort, Time Perspective: Prospective
Positional Stability of Metallic Markers in the Breast Parenchyma
To validate that intraparenchymal metallic markers placed in the breast tissue can be used as stable markers throughout a course of radiation treatment for daily image guided localization. Image Guided Radiation Therapy (IGRT) will be deemed feasible if the average shift in marker position results in deviations of up to 7 mm from the initial position.
Completion of planned radiation treatment.
Eleanor Harris, M.D.
H. Lee Moffitt Cancer Center and Research Institute, Inc.
United States: Institutional Review Board
|H. Lee Moffitt Cancer Center and Research Institute, Inc.||Tampa, Florida 33612|