Inclusion/Exclusion Criteria for Normal Cohort

Inclusion Criteria:

- All study subjects should be able to provide informed consent

- Males or females ages 40 years or older (see section A8 for the rationale for the
inclusion of females)

- Individuals of Arab descent from Qatari peninsula without any personal or family
history of prostate cancer

Exclusion Criteria:

- Individuals with family history of prostate cancer

- Individuals not deemed in good overall health by the investigator will not be
accepted into the study

Inclusion/Exclusion Criteria for Prostate Cohort

Inclusion Criteria:

- All study subjects should be able to provide informed consent

- Males ages 40 years or older

- Individuals from the Qatari Peninsula whose ancestors up to three generations back
were natives of Qatar.

- Individuals undergoing Trans Rectal Ultrasound (TRUS) biopsy as dictated by their
standard clinical care

- Ultrasound OR digital rectal examination consistent with prostate disease OR A level
of PSA (Prostatic Specific Antigen) greater than 3.0

Exclusion Criteria:

• Patient refuses consent