Inclusion Criteria:

Healthy volunteers (Part 1 only)

- males, 18-45 years of age;

- no history of hypersensitivity or allergic reaction, spontaneous or following drug
administration;

- no history of cardiac conditions. Patients (Part 1 and 2)

- females, >=18 years of age;

- ECOG performance status of 0;

- previous non-metastatic operable primary invasive HER2 positive breast cancer;

- baseline LVEF >55%.

Exclusion Criteria:

Healthy volunteers (Part 1 only)

- clinically significant abnormalities in laboratory test results or ECGs;

- LVEF<60%;

- history of significant allergies, gastrointestinal, renal, hepatic, cardiovascular or
pulmonary disease.

patients (Parts 1 and 2)

- metastatic disease;

- concurrent other malignancy requiring therapy of any modality which may interfere
with PK investigations or result in unexpected toxicity;

- use of herception in previous 5 months;

- serious cardiac illness.