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Does Endometrial Injury in the Non-Transfer Cycle Improve the IVF-ET Outcome in the Subsequent Cycle in Patients With Previous Failed IVF Cycles: A Randomized Control Trial


N/A
18 Years
37 Years
Not Enrolling
Female
Infertility

Thank you

Trial Information

Does Endometrial Injury in the Non-Transfer Cycle Improve the IVF-ET Outcome in the Subsequent Cycle in Patients With Previous Failed IVF Cycles: A Randomized Control Trial


Study Design and Subjects: This is a randomized control study designed to evaluate the
effect of local injury to the endometrium in non-transfer cycle in patients with previous
failed IVF.

Patients will be randomly allotted to control and intervention group The patients in the
intervention group Pipelle endometrial sampling 7-10th day and 24-26th day in the cycle
prior to IVF transfer cycle.

Outcome Measures: Clinical pregnancy rate,implantation rate and ongoing pregnancy rate.

SAMPLE SIZE: 100 PATIENTS (50 in each group).


Inclusion Criteria:



- Previous failed In-vitro fertilization embryo transfer cycle

- Patients who are good responders and have good quality embryos in the previous
attempts

- Age of patients upto 37yrs

Exclusion Criteria:

- Those detected to have endometrial tuberculosis in the past, including those treated
with Antituberculosis treatment

- Those with intramural fibroid distorting the endometrial cavity/sub-mucous myoma

- Those with sonographically detected hydrosalpinx

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

PRIMARY OUTCOME MEASURE:IMPLANTATION RATE;

Outcome Time Frame:

9 MONTHS

Safety Issue:

No

Principal Investigator

SACHIN A NARVEKAR, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Bangalore Assisted Conception Centre

Authority:

India: Institutional Review Board

Study ID:

endometrial injury study

NCT ID:

NCT00796341

Start Date:

November 2007

Completion Date:

September 2008

Related Keywords:

  • Infertility
  • invitro-fertilization ,embryo transfer,endometrial injury
  • Infertility
  • Adenoma

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