A Phase Ⅲ Randomized Clinical Trial of Postmastectomy Hypofractionation Radiotherapy in High-risk Breast Cancer
Eligible breast cancer patients with mastectomy and axillary dissection are randomized into
2 groups:conventional fractionation radiotherapy of 50 Gy in 25 fractions within 5 weeks to
ipsilateral chest wall and supraclavicular nodal region,and hypofractionation radiotherapy
of 43.5Gy in 15 fractions within 3 weeks to the same region.
During and after radiotherapy, the patients are followed and the efficacy and toxicities of
radiotherapy are evaluated.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
locoregional control rate
shu-lian wang, M.D.
Cancer Hospital, Chinese Academy of Medical Sciences
China: Ethics Committee