Know Cancer

forgot password

S0718: Phase I Study Evaluating The Combination of GW786034 (Pazopanib; NSC-737754; IND-XXXX) and CCI-779 (Temsirolimus; NSC-683864; IND-XXXX) in Patients With Advanced Solid Tumors

Phase 1
18 Years
Not Enrolling
Unspecified Adult Solid Tumor, Protocol Specific

Thank you

Trial Information

S0718: Phase I Study Evaluating The Combination of GW786034 (Pazopanib; NSC-737754; IND-XXXX) and CCI-779 (Temsirolimus; NSC-683864; IND-XXXX) in Patients With Advanced Solid Tumors


- To investigate the safety and feasibility of temsirolimus and pazopanib when given in
combination in patients with advanced solid tumors.

- To recommend the maximum tolerated dose of this regimen in these patients.

- To investigate the pharmacokinetics of temsirolimus alone and in combination with
pazopanib in these patients.

- To investigate the effects of this regimen on relevant biological markers.

- To preliminarily report objective response in patients treated with this regimen.

OUTLINE: This is a multicenter study.

Patients receive temsirolimus IV over 30 minutes on days 1, 8,15, and 22 and oral pazopanib
hydrochloride once daily on days 4-28 in course 1 and days 1-28 in all subsequent courses.
Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Blood samples are obtained periodically for evaluation of the pharmacokinetics of
temsirolimus and pazopanib, plasma and serum angiogenic and cachectic factors (e.g., VEGF,
bFGF, PlGF and SDF-1) by enzyme-linked immunosorbent assay, and biological markers in the
mTOR/PI3/Akt, Ras/MAPK, VEGFR, PDGFR, and HIF-1 pathways.

After completion of study therapy, patients are followed for 28 days.

Inclusion Criteria


- Cytologically or pathologically verified cancer that is of advanced stage and for
which there is no effective therapy

- No lymphoma

- Measurable or nonmeasurable disease

- Previously irradiated (whole brain or gamma knife) brain metastases allowed provided
there is no requirement for corticosteroids or anticonvulsants


- Zubrod performance status 0-2

- ANC ≥ 1,500/mm³

- Platelet count ≥ 100,000/mm³

- Hemoglobin ≥ 9 g/dL (without transfusions)

- AST and ALT ≤ 2.5 times upper limit of normal (ULN) (≤ 5 times ULN if liver
metastases present)

- Bilirubin normal

- Serum creatinine ≤ 1.5 times ULN OR measured creatinine clearance OR calculated
creatinine clearance ≥ 60 mL/min

- QTC interval < 480 msec on baseline ECG OR average QTC < 480 msec on baseline plus 2
additional screening ECG's

- Fasting cholesterol < 350 mg/dL

- Fasting triglycerides < 400 mg/dL

- No uncontrolled hypertension, arterial thrombotic event, or bleeding on therapeutic
anticoagulation with warfarin or heparin (including low molecular weight heparin)
within the past 6 months

- Able to swallow enteral medications

- No feeding tubes

- No intractable nausea or vomiting

- No gastrointestinal (GI) tract disease resulting in an inability to take oral
medication, malabsorption syndrome, a requirement for IV alimentation, prior surgical
procedures affecting absorption, or uncontrolled inflammatory GI disease (e.g.,
Crohn, ulcerative colitis)

- No history of allergic reactions attributed to compounds of similar chemical or
biologic composition to rapamycin analogs (e.g., sirolimus and everolimus)

- No known HIV positivity

- No uncontrolled intercurrent illness including, but not limited to, the following:

- Ongoing or serious active infection

- Symptomatic congestive heart failure

- Unstable angina pectoris

- Serious cardiac arrhythmia

- History of myocardial infarction

- Cerebrovascular accident within 3 months of study entry

- Uncontrolled diarrhea

- Psychiatric illness or social situation that would limit compliance with study

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception, including barrier methods

- Willing to undergo pharmacokinetic (PK) sampling and blood submission for PK and
translational medicine studies


- Recovered from all prior therapy

- No prior pazopanib hydrochloride or temsirolimus

- More than 28 days since prior major surgery, chemotherapy, biologic therapy, or

- More than 28 days since prior investigational agents

- At least 14 days since prior radiotherapy

- No concurrent rapamycin (sirolimus)

- No concurrent enzyme-inducing antiepileptic drugs (e.g., phenytoin, carbamazepine, or
phenobarbital), CYP3A4 inducers (e.g., rifampin or St. John's wort), or CYP3A4
inhibiting agents or substrates (e.g., ketoconazole, diltiazem, or verapamil)

- No concurrent chemotherapy, hormonal therapy, radiotherapy, immunotherapy, or any
other type of therapy for treatment of this cancer while on this protocol

- No live vaccines

- Luteinizing-hormone releasing-hormone agonists allowed

- Concurrent prophylactic warfarin (≤ 1 mg/day) allowed

- Concurrent bisphosphonate or erythropoietin or its analogue allowed, if deemed
appropriate by the treating physician

Type of Study:


Study Design:

Primary Purpose: Treatment

Outcome Measure:

Safety as assessed by NCI CTCAE v3.0

Safety Issue:


Principal Investigator

Claire F. Verschraegen, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of New Mexico Cancer Center


United States: Food and Drug Administration

Study ID:




Start Date:

Completion Date:

Related Keywords:

  • Unspecified Adult Solid Tumor, Protocol Specific
  • unspecified adult solid tumor, protocol specific
  • Neoplasms