Functional Metabolic Near-infrared Tomographic Optical Breast Imaging (TOBI) to Monitor Response to Neoadjuvant Therapy in Breast Cancer
- Participants will have a TOBI scan prior to starting their cancer treatment and again
on day 8 after their first treatment. Participants will also be asked if they would
volunteer to undergoing one or more additional TOBI scans on days 2-7 after they begin
cancer treatment. These additional scans are optional. Participants will also have a
scan on the first day of each treatment cycle.
- TOBI scans will be performed at the Gillette Center for Breast Cancer at the
Massachusetts General Hospital.
- For the scan, each breast is placed between 2 plastic plates in order to spread the
tissue apart, similar to the procedure for a mammogram. The TOBI scanner is attached
to these plates. We will apply mild pressure to compress the breast and the breast
will be scanned using light waves. Each scan will take about 3 minutes.
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
To explore the feasibility of measuring optically derived parameters in the clinical setting.
Steven Isakoff, MD, PhD
Massachusetts General Hospital
United States: Food and Drug Administration
|Massachusetts General Hospital||Boston, Massachusetts 02114-2617|