A Phase II Trial Evaluating the Role of Posterior Fossa Irradiation (PFI) Plus Stereotactic Radiosurgery (SRS) for Cerebellar Metastases
SCHEMA:
- Posterior Fossa Irradiation as defined by diagnostic MRI and CT simulation.
- 37.5 Gy in 2.5 Gy fractions administered via conformal beams.
- Radiosurgical boost (with dose titrated to parameters of RTOG 9005).
- Contrast enhanced MRI will be obtained at baseline and then at 3, 6, and 12 months
following completion of posterior fossa irradiation.
- The Mini Mental Status Examination will be used to evaluate global cognitive function
at baseline and then at 3, 6, and 12 months following completion of posterior fossa
irradiation.
Interventional
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
To determine tumor control rates in the brain following posterior fossa irradiation of patients with cerebellar metastases.
1 year
No
Ben Corn, Prof.
Principal Investigator
Radiotherapy Department, TASMC
Israel: Ministry of Health
TASMC - 08 - BC - 270 - CTIL
NCT00781209
October 2008
December 2010
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